Synthesis of 13N-labelled polysubstituted triazoles via Huisgen cycloaddition
نویسندگان
چکیده
منابع مشابه
An Efficient Synthesis of 1,4-Disubstituted Triazoles in Water via CuCl2/Zn-Catalyzed Huisgen Cycloaddition
Triazoles are an important class of heterocyclic compounds. In recent years 1,2,3-triazoles gained more and more interest due to their diverse biological activities and synthetic methodology [1 – 3]. An efficient approach for constructing the 1,2,3-triazole unit is the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, which was discovered independently by the groups of Sharpless ...
متن کاملSynthesis of bi- and bis-1,2,3-triazoles by copper-catalyzed Huisgen cycloaddition: A family of valuable products by click chemistry
The Cu(I)-catalyzed azide-alkyne cycloaddition reaction, also known as click chemistry, has become a useful tool for the facile formation of 1,2,3-triazoles. Specifically, the utility of this reaction has been demonstrated by the synthesis of structurally diverse bi- and bis-1,2,3-triazoles. The present review focuses on the synthesis of such bi- and bistriazoles and the importance of using cop...
متن کاملCytotoxic conjugates of betulinic acid and substituted triazoles prepared by Huisgen Cycloaddition from 30-azidoderivatives
In this work, we describe synthesis of conjugates of betulinic acid with substituted triazoles prepared via Huisgen 1,3-cycloaddition. All compounds contain free 28-COOH group. Allylic bromination of protected betulinic acid by NBS gave corresponding 30-bromoderivatives, their substitution with sodium azides produced 30-azidoderivatives and these azides were subjected to CuI catalysed Huisgen 1...
متن کاملSynthesis of azasilacyclopentenes and silanols via Huisgen cycloaddition-initiated C-H bond insertion cascades.
An unusual transition metal-free cascade reaction of alkynyl carbonazidates was discovered to form azasilacyclopentenes. Mild thermolysis afforded the products via a series of cyclizations, rearrangements, and an α-silyl C-H bond insertion (rather than the more common Wolff rearrangement, 1,2-shift, or β-silyl C-H insertion) to form silacyclopropanes. A mechanistic proposal for the sequence was...
متن کاملSynthesis of fluorophosphonylated acyclic nucleotide analogues via copper(I)-catalyzed Huisgen 1-3 dipolar cycloaddition.
Preparation of several acyclonucleosides containing both a difluoromethylphosphonate group and a triazole moiety is described starting from a difluorophosphonosulfide. The key step of the synthesis involves a copper(I)-catalyzed Huisgen 1-3 dipolar cycloaddition between difluorophosphonylated azides and propargylated nucleobases derived from thymine and 2-amino-6-chloropurine.
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ژورنال
عنوان ژورنال: RSC Advances
سال: 2016
ISSN: 2046-2069
DOI: 10.1039/c6ra24670b